Noonindoles G–L: Indole Diterpene Glycosides from the Australian Marine-Derived Fungus Aspergillus noonimiae CMB-M0339

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By NCBI Pubmed Posted on Jan 20, 2023
In Category - Other, Nature
Sarani Kankanamge, Zeinab G. Khalil, Thulasi Sritharan, Robert J. Capon
1. Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia

Journal of Natural Products (ACS Publications) 2023
10.1021/acs.jnatprod.2c01024
English
J. Nat. Prod. 2023, XXXX, XXX, XXX-XXX Publication Date:January 20, 2023 https://doi.org/10.1021/acs.jnatprod.2c01024. Share Research.
Abstract
Fungal indole diterpenes (IDTs) occupy a valuable region of bioactive natural product chemical space, displaying potent and selective inhibition of therapeutically important ion channels and with potential application in the treatment of glaucoma, cancer, and neurodegenerative diseases, as well as insecticides and antivirals. We have employed an integrated workflow of analytical scale chemical profiling using GNPS (Global Natural Products Social molecular networking) and cultivation profiling (also known as “MATRIX” miniaturized microbioreactor) to detect, prioritize, optimize the production, isolate, characterize, and identify a new series of indole diterpenes, noonindoles G–L (7–12), from an Australian marine-derived fungus, Aspergillus noonimiae CMB-M0339. The first reported examples of IDT glycosides, the molecular structures for 7–12, were assigned on the basis of detailed spectroscopic analysis and biosynthetic considerations.

Fungal indole diterpenes (IDTs) occupy a valuable region of bioactive natural product chemical space, displaying potent and selective inhibition of therapeutically important ion channels and with potential application in the treatment of glaucoma, cancer, and neurodegenerative diseases, as well as insecticides and antivirals. We have employed an integrated workflow of analytical scale chemical profiling using GNPS (Global Natural Products Social molecular networking) and cultivation profiling (also known as “MATRIX” miniaturized microbioreactor) to detect, prioritize, optimize the production, isolate, characterize, and identify a new series of indole diterpenes, noonindoles G–L (7–12), from an Australian marine-derived fungus, Aspergillus noonimiae CMB-M0339. The first reported examples of IDT glycosides, the molecular structures for 7–12, were assigned on the basis of detailed spectroscopic analysis and biosynthetic considerations.

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